Increased bile resistance in Salmonella enterica mutants lacking Prc periplasmic protease
Autor: | Hernández, Sara B., Ayala, Juan Alfonso, Rico-Pérez, Gadea, García del Portillo, Francisco, Casadesús, Josep |
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Rok vydání: | 2013 |
Předmět: | |
Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
Popis: | Prc is a periplasmic protease involved in processing of penicillin-binding protein 3 (PBP3). Lack of Prc suppresses bile sensitivity in Dam-, Wec-, PhoP-, DamX-, and SeqA- mutants of Salmonella enterica, and increases bile resistance in the wild type. Changes in the activity of penicillin binding proteins PBP3, PBP4, PBP5/6 and PBP7 are detected in a Prc- background, suggesting that peptidoglycan remodeling might contribute to bile resistance. Spanish Government; European Regional Fund (grants BIO2010-15023, BIO2010-18885, and BFU2009-09200); Consejería de Innovación, Ciencia y Empresa; Junta de Andalucía (grant CVI-5879); Spanish Ministry of Education and Culture |
Databáze: | OpenAIRE |
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