Standardization procedure for flow cytometry data harmonization in prospective multicenter studies

Autor:	Lucas Le Lann, Pierre-Emmanuel Jouve, Marta Alarcón-Riquelme, Christophe Jamin, Jacques-Olivier Pers, Blanco Alonso, Ricardo, González-Gay Mantecón, Miguel Ángel
Přispěvatelé:	Universidad de Cantabria
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	lcsh:R Leukocytes lcsh:Medicine Humans lcsh:Q Prospective Studies Reference Standards lcsh:Science Flow Cytometry Biomarkers
Zdroj:	Scientific Reports 10, 11567 (2020). UCrea Repositorio Abierto de la Universidad de Cantabria instname Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Popis:	One of the most challenging objective for clinical cytometry in prospective multicenter immunomonitoring trials is to compare frequencies, absolute numbers of leukocyte populations and further the mean fluorescence intensities of cell markers, especially when the data are generated from different instruments. Here, we describe an innovative standardization workflow to compare all data to carry out any large-scale, prospective multicentric flow cytometry analysis whatever the duration, the number or type of instruments required for the realization of such projects
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6fe3f43a216c3734e7a3e0e294e194d3 https://www.nature.com/articles/s41598-020-68468-3.pdf Zobrazit plný text záznamu