| Autor: |
Dobie, R., MacRae, V.E., Huesa, C., van't Hof, R., Ahmed, S.F., Farquharson, C. |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Zdroj: |
JOURNAL OF ENDOCRINOLOGY |
| ISSN: |
0022-0795 |
| Popis: |
The suppressor of cytokine signalling (Socs2−/−)-knockout mouse is characterised by an overgrowth phenotype due to enhanced GH signalling. The objective of this study was to define the Socs2−/− bone phenotype and determine whether GH promotes bone mass via IGF1-dependent mechanisms. Despite no elevation in systemic IGF1 levels, increased body weight in 4-week-old Socs2−/− mice following GH treatment was associated with increased cortical bone area (Ct.Ar) (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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