Iridium-catalyzed C4-alkylation of 2,6-di-tert-butylphenol by using hydrogen-borrowing catalysis
| Autor: | Frost, J, Cheong, C, Donohoe, T |
|---|---|
| Rok vydání: | 2016 |
| Zdroj: | Synthesis. 49(4) |
| ISSN: | 1437-210X 0039-7881 |
| Popis: | An iridium-catalyzed hydrogen borrowing process has been developed whereby 2,6-di-tert-butylphenol can be alkylated at the C4-position using a range of different primary alcohols (11 examples, 40–93% yield). Following this, a selection of the products obtained underwent retroFriedel–Crafts reaction to provide para-substituted phenols which could potentially undergo further synthetic manipulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|