| Autor: |
Yasuhisa Tatebe, Kanamitsu, K., Kanzaki, H., Ishida, H., Fujiwara, K., Washio, K., Kitamura, Y., Sendo, T., Shimada, A., Tsukahara, H. |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| ISSN: |
0386-300X |
| Popis: |
Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination. We present a case of a pediatric patient with acute lymphoblastic leukemia who suffered from persistently high plasma methotrexate concentrations and acute kidney injuries after the admin-istration of a medium dose of methotrexate. Subsequent genetic analysis showed that he was a carrier of dys-functional genetic variants associated with methotrexate clearance. This case highlights that polymorphisms of methotrexate transporter pathways can adversely affect methotrexate elimination in a clinically significant manner. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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