Splicing Deregulation and Splicing Modulation in Acute Myeloid Leukemia: DNA is not Destiny
| Autor: | van der Werf, IM |
|---|---|
| Přispěvatelé: | Kaspers, Gertjan, Cloos, Jacqueline, Wojtuszkiewicz, Anna, Groen, Richard, Hematology laboratory, Kaspers, G.J.L., Cloos, J., Wojtuszkiewicz, Anna Monika, Groen, R. |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Acute Myeloid Leukemia
FLT3/ITD Alternatieve Splicing SF3B1 Pediatric Acute Myeloid Leukemia Splicing Factor Mutation Alternative Splicing Splicing Deregulatie hemic and lymphatic diseases Leukemie in Kinderen Acute Myeloïde Leukemie Splicing Regulator Mutatie Splicing Modulation Splicing Deregulation neoplasms Splicing Modulatie |
| Zdroj: | van der Werf, I M 2022, ' Splicing Deregulation and Splicing Modulation in Acute Myeloid Leukemia : DNA is not Destiny ', Dr., Vrije Universiteit Amsterdam . van der Werf, IM 2022, ' Splicing Deregulation and Splicing Modulation in Acute Myeloid Leukemia: DNA is not Destiny ', Doctor of Philosophy, Vrije Universiteit Amsterdam, Netherlands . < https://hdl.handle.net/1871.1/d8faf35c-e79a-4702-85e8-47a781d2fc41 > |
| Popis: | Cancer is thought to arise from accumulation of DNA mutations. However, AML is a heterogeneous disease characterized by diverse mutations each occurring at low frequencies. Actually, AML is a subtype with a relatively low mutational load compared to other cancer types. In addition, in children, DNA is far less damaged by exposure or age. Thus, also AML might not only be driven by differences in genomic content but also by transcriptomic heterogeneity. In this thesis we aimed to study deregulated splicing in AML and uncover its role in leukemogenesis. |
| Databáze: | OpenAIRE |
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