Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis
| Autor: | Stopa, Edward G, Tanis, Keith Q, Miller, Miles C, Nikonova, Elena V, Podtelezhnikov, Alexei A, Finney, Eva M, Stone, David J, Camargo, Luiz M, Parker, Lisan, Verma, Ajay, Baird, Andrew, Donahue, John E, Torabi, Tara, Eliceiri, Brian P, Silverberg, Gerald D, Johanson, Conrad E |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cadherin-mediated adhesion Aging CSF homocysteine LRP-1 Gene Expression Peroxisome-proliferator-activated receptor (PPAR) Peroxisome-proliferator-activated receptor Neurodegenerative Alzheimer's Disease Medical and Health Sciences Janus kinase/signal transducers and activators of transcription (JAK-STAT) Rare Diseases Alzheimer Disease 80 and over Acquired Cognitive Impairment Genetics Humans Homeostasis Mechanistic target of rapamycin (mTOR) Choroid plexus transcriptome Aged Neurosciences Blood-CSF barrier inflammatome Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) Middle Aged Neuroimmune CSF regulation Biological Sciences Microarray Analysis Blood–CSF barrier inflammatome Brain Disorders Huntington Disease Frontotemporal Dementia Choroid Plexus Neurological Female Dementia Janus kinase/signal transducers and activators of transcription Vascular endothelial growth factor Transcriptome Mechanistic target of rapamycin Choroid plexus methionine |
| Zdroj: | Fluids and barriers of the CNS, vol 15, iss 1 Stopa, EG; Tanis, KQ; Miller, MC; Nikonova, EV; Podtelezhnikov, AA; Finney, EM; et al.(2018). Comparative transcriptomics of choroid plexus in Alzheimer's disease, frontotemporal dementia and Huntington's disease: implications for CSF homeostasis. FLUIDS AND BARRIERS OF THE CNS, 15. doi: 10.1186/s12987-018-0102-9. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/4tn4j1xw |
| DOI: | 10.1186/s12987-018-0102-9. |
| Popis: | BACKGROUND:In Alzheimer's disease, there are striking changes in CSF composition that relate to altered choroid plexus (CP) function. Studying CP tissue gene expression at the blood-cerebrospinal fluid barrier could provide further insight into the epithelial and stromal responses to neurodegenerative disease states. METHODS:Transcriptome-wide Affymetrix microarrays were used to determine disease-related changes in gene expression in human CP. RNA from post-mortem samples of the entire lateral ventricular choroid plexus was extracted from 6 healthy controls (Ctrl), 7 patients with advanced (Braak and Braak stage III-VI) Alzheimer's disease (AD), 4 with frontotemporal dementia (FTD) and 3 with Huntington's disease (HuD). Statistics and agglomerative clustering were accomplished with MathWorks, MatLab; and gene set annotations by comparing input sets to GeneGo ( http://www.genego.com ) and Ingenuity ( http://www.ingenuity.com ) pathway sets. Bonferroni-corrected hypergeometric p-values of |
| Databáze: | OpenAIRE |
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