Enterococcus faecalis Endocarditis and Outpatient Treatment: A Systematic Review of Current Alternatives

Autor: Herrera-Hidalgo, Laura, de Alarcón, Arístides, López-Cortes, Luis E., Luque-Márquez, Rafael, López-Cortes, Luis F., Gutiérrez-Valencia, Alicia, Gil-Navarro, María V.
Přispěvatelé: [Herrera-Hidalgo,L, Gil-Navarro,MV] Unidad de Gestión Clinica de Farmacia, Hospital Universitario Virgen del Rocío/CSIC/Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain. [de Alarcón,A, Luque-Márquez,R, López-Cortes,LF, Gutiérrez-Valencia,A] Unidad de Gestión Clinica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen del Rocío/CSIC/Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain. [López-Cortes,LE] Unidad de Gestión Clinica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena/CSIC/Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain. [Gutiérrez-Valencia,A] Infección por el VIH y farmacocinética de antivirals, Instituto de Biomedicina de Sevilla (IBiS), Seville, Spain., AGV was supported by the Instituto de Salud Carlos III, cofinanced by the European Development Regional Fund ('A way to achieve Europe'), Subprograma Miguel Servet (grant CP19/00159). LHH was supported by the Instituto de Salud Carlos III, Subprograma Rio Hortega (grant CM19/00152).
Rok vydání: 2020
Předmět:
Persons::Persons::Patients::Outpatients [Medical Subject Headings]
Endocarditis
Aminoglicósidos
Chemicals and Drugs::Carbohydrates::Glycosides::Aminoglycosides [Medical Subject Headings]
Revisión sistemática
Analytical
Diagnostic and Therapeutic Techniques and Equipment::Therapeutics [Medical Subject Headings]
Atención ambulatoria
Treatment alternatives
Health Care::Health Care Facilities
Manpower
and Services::Health Services::Patient Care::Ambulatory Care [Medical Subject Headings]
Outpatient parenteral antibiotic treatment (OPAT)
Beta-Lactamas
Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Enterococcaceae::Enterococcus::Enterococcus faecalis [Medical Subject Headings]
Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams [Medical Subject Headings]
Enterococcus faecalis
Outpatient treatment
Systematic review
Infective endocarditis
Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents [Medical Subject Headings]
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
Popis: © 2020 by the authors. The selection of the best alternative for Enterococcus faecalis infective endocarditis (IE) continuation treatment in the outpatient setting is still challenging. Three databases were searched, reporting antibiotic therapies against E. faecalis IE in or suitable for the outpatient setting. Articles the results of which were identified by species and treatment regimen were included. The quality of the studies was assessed accordingly with the study design. Data were extracted and synthesized narratively. In total, 18 studies were included. The treatment regimens reported were classified regarding the main antibiotic used as regimen, based on Aminoglycosides, dual β-lactam, teicoplanin, daptomycin or dalbavancin or oral therapy. The regimens based on aminoglycosides and dual β-lactam combinations are the treatment alternatives which gather more evidence regarding their efficacy. Dual β-lactam is the preferred option for high level aminoglycoside resistance strains, and for to its reduced nephrotoxicity, while its adaptation to the outpatient setting has been poorly documented. Less evidence supports the remaining alternatives, but many of them have been successfully adapted to outpatient care. Teicoplanin and dalbavancin as well as oral therapy seem promising. Our work provides an extensive examination of the potential alternatives to E. faecalis IE useful for outpatient care. However, the insufficient evidence hampers the attempt to give a general recommendation.
Databáze: OpenAIRE
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