Specificity proteins 1 and 4, hippocampal volume and first-episode psychosis
| Autor: | Fusté M, Meléndez-Pérez I, Villalta-Gil V, Pinacho R, Villalmanzo N, Narcis Cardoner, Jm, Menchón, Jm, Haro, Soriano-Mas C, Ramos B |
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| Rok vydání: | 2016 |
| Zdroj: | BRITISH JOURNAL OF PSYCHIATRY r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu Europe PubMed Central |
| ISSN: | 0007-1250 |
| Popis: | We assessed specificity protein 1 (SP1) and 4 (SP4) transcription factor levels in peripheral blood mononuclear cells and conducted a voxel-based morphometry analysis on brain structural magnetic resonance images from 11 patients with first-episode psychosis and 14 healthy controls. We found lower SP1 and SP4 levels in patients, which correlated positively with right hippocampal volume. These results extend previous evidence showing that such transcription factors may constitute a molecular pathway to the development of psychosis. |
| Databáze: | OpenAIRE |
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