Assessment of clinical symptoms in household contacts of confirmed pertussis cases

Autor: Domínguez A, Soldevila N, Caylà JA, García-Cenoz M, Ferrús G, Sala-Farré MR, Álvarez J, Carol M, Barrabeig I, Camps N, Coronas L, Munoz-Almagro C, Godoy P
Rok vydání: 2017
Předmět:
Zdroj: JOURNAL OF INFECTION
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
ISSN: 0163-4453
Popis: Objectives: We assessed the value of the clinical symptoms included in the case definition of pertussis in household contacts of laboratory-confirmed cases. Methods: A prospective epidemiological study was made in two Spanish regions. Household contacts were identified for each confirmed case reported during 2012 and 2013. Two clinical samples were taken to determine the presence or absence of Bordetella pertussis by culture or real-time PCR. Clinical variables, age and vaccination status were recorded. Positive and negative likelihood ratios (PLR, NLR) were estimated for each symptom. Results: 2852 household contacts of 688 confirmed cases were reported. 178 household contacts with clinical symptoms were analyzed: 150 were laboratory confirmed and 28 were not. The clinical symptom with the highest PLR in comparison with the NLR was paroxysmal cough PLR 4.76; 95% CI 1.91-11.87 and NLR 0.37; 95% CI 0.28-0.49). The contrast between the PLR and NLR was especially important for persons aged
Databáze: OpenAIRE
Externí odkaz: