Immunohistochemical study of cyclin A and p16 expression in patients with renal cell carcinoma
| Autor: | Latic, D., Radojevic-Skodric, S., srdjan nikolic, Prvanovic, M., Lazic, M., Dzamic, Z., Bogdanovic, L., Radunovic, M., Vukovic, M. |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Journal of BUON Scopus-Elsevier |
| Popis: | Purpose: Renal cell carcinoma (RCC) is the most common malignant kidney tumor in adults. Dysregulation of the cell cycle can lead to cancer development. In this study, the mitosis-associated cyclin A and p16, a negative controller, were investigated as potential key points in the RCC development. Methods: This retrospective study included 74 patients with RCC. The expression of cyclin A and p16 and their correlation to histopathological parameters (TNM stage, histological subtype, nuclear grade, tumor size), gender, age, and clinical outcome were studied and analyzed. Results: The highest median value for cyclin A (40%; range 0-70)) and for p16 (57.5%; range 35-80) were found in the papillary histological subtype. Survival analysis showed that in the group of patients that had died before September 2015, the median value for cyclin A was 20% (range 0-60), which was significantly higher than 5% (range 0-70), found in the group of patients that survived (p=0.019). Conclusions: In relation to the histological subtype, the papillary type of RCC was associated with a significantly higher expression of cyclin A and p16 compared to other subtypes of RCC. High expression of cyclin A indicated worse prognosis, therefore cyclin A could be considered to be a significant prognostic marker. |
| Databáze: | OpenAIRE |
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