Phosphorylation of gH2AX as a novel prognostic biomarker for laryngoesophageal dysfunction-free survival
| Autor: | Miguel Luken, MJ de, Chaves Conde, M, Quintana, Begoña, Menoyo, Alicia, Tirado, Isabel, Miguel Luken, Veronica de, Pachón Díaz, Jerónimo, Carnero Moya, Amancio |
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| Přispěvatelé: | Universidad de Sevilla. Departamento de Medicina, Universidad de Sevilla. Departamento de Cirugía, Universidad de Sevilla. CTS203: Estudio de las enfermedades infecciosas |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | idUS: Depósito de Investigación de la Universidad de Sevilla Universidad de Sevilla (US) idUS. Depósito de Investigación de la Universidad de Sevilla instname |
| Popis: | Current larynx preservation treatments have achieved an improvement of laryngoesophageal dysfunction-free survival (LDS) but lead to significant toxicities and recurrences. At present, there is no evidence to select the group of patients that may benefit from preservation approaches instead of surgery. Therefore, laryngeal biomarkers could facilitate pretreatment identification of patients who could respond to chemoradiation-based therapy. In this study, we evaluated retrospectively 53 patients with larynx cancer to determine whether gH2AX phosphorylation (pH2AX) alone or in combination with the membrane protein MAP17 (PDZK1IP1) could be used as prognostic biomarkers. We also evaluated whether the completion of cisplatin treatment and radiotherapy could predict survival in combination with pH2AX. We found that the dose of cisplatin received but not the length of the radiotherapy influenced LDS. High-pH2AX expression was associated with prolonged LDS (HR 0.26, p = 0.02) while MAP17 correlated with overall survival (OS) (HR 0.98, p = 0.05). High-MAP17 and high-pH2AX combined analysis showed improved LDS (with 61.35 months vs 32.2 months, p = 0.05) and OS (with 66.6 months vs 39.8 months, p = 0.01). Furthermore, the subgroup of high-pH2AX and optimal dose of cisplatin was also associated with OS (72 months vs 38.6 months, p = 0.03) and LDS (66.9 months vs 27 months, p = 0.017). These findings suggest that pH2AX alone or better in combination with MAP17 may become a novel and valuable prognostic biomarker for patients with laryngeal carcinoma treated with preservation approaches. Junta de Andalucia ISCIII-Red de Biobancos RD12/0036/0017. Unión Europea, Ministerio de Economía y Competitividad PI12/00137, PI15/00045, RTICC: RD12/0036/0028 Junta de Andalucía CTS-6844; CTS-1848 Junta de Andalucía PI-0135-2010; PI-0306-2012 Instituto Carlos III (ISCIII) PIE13/0004. |
| Databáze: | OpenAIRE |
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