Censoring exosomal crosstalk in osteoarthritis

Autor: Pegtel, DM, Baglio, SR, Meulenbelt, Ingrid
Přispěvatelé: Pathology, AII - Inflammatory diseases
Jazyk: angličtina
Rok vydání: 2021
Zdroj: Pegtel, DM, Baglio, SR & Meulenbelt, I 2021, ' Censoring exosomal crosstalk in osteoarthritis ', Nature Aging, pp. 332 .
Nature Aging
ISSN: 2662-8465
Popis: Using mouse models of osteoarthritis (OA), a new study finds that osteoclasts secrete exosomes that deliver miRNAs to chondrocytes, leading to an increase in metalloproteinase activity in cartilage. A bone-specific inhibitor of exosome production can halt this process, hinting at a new therapeutic strategy for patients with OA.
Databáze: OpenAIRE
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