GOLLUM [FeFe]-hydrogenase-like proteins are essential for plant development in normoxic conditions and modulate energy metabolism

Autor: Mondy, Samuel, Lenglet, Aurore, Cosson, Viviane, Pelletier, Sandra, Pateyron, Stephanie, Gilard, Françoise, Scholte, Marije, Brocard, Lysiane, Couzigou, Jean-Malo, Tcherkez, Guillaume, Péan, Michel, Ratet, Pascal
Přispěvatelé: Institut des sciences du végétal (ISV), Centre National de la Recherche Scientifique (CNRS), Unité de recherche en génomique végétale (URGV), Institut National de la Recherche Agronomique (INRA)-Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11), Aix Marseille Université (AMU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), French MENRT, French ANR SEPTANTE programme
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Plant, Cell and Environment
Plant, Cell and Environment, Wiley, 2014, 37 (1), pp.54-69. ⟨10.1111/pce.12128⟩
Plant, Cell and Environment, 37(1), 54-69
Plant, Cell and Environment, 2014, 37 (1), pp.54-69. ⟨10.1111/pce.12128⟩
Plant, Cell and Environment 37 (2014) 1
ISSN: 0140-7791
1365-3040
DOI: 10.1111/pce.12128⟩
Popis: International audience; [FeFe]-hydrogenase-like genes encode [Fe4S4]-containing proteins that are ubiquitous in eukaryotic cells. In humans, iron-only hydrogenase-like protein 1 (IOP1) represses hypoxia inducible factor-1 subunit (HIF1-) at normal atmospheric partial O-2 pressure (normoxia, 21kPa O-2). In yeasts, the nar1 mutant cannot grow at 21kPa O-2,O- but can develop at a lower O-2 pressure (2kPa O-2). We show here that plant [FeFe]-hydrogenase-like GOLLUM genes are essential for plant development and cell cycle progression. The mutant phenotypes of these plants are seen in normoxic conditions, but not under conditions of mild hypoxia (5kPa O-2). Transcriptomic and metabolomic experiments showed that the mutation enhances the expression of some hypoxia-induced genes under normal atmospheric O-2 conditions and changes the cellular content of metabolites related to energy metabolism. In conclusion, [FeFe]-hydrogenase-like proteins play a central role in eukaryotes including the adaptation of plants to the ambient O-2 partial pressure.
Databáze: OpenAIRE
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