| Autor: |
Kirmizibekmez, H., Bassarello, C., Piacente, S., Celep, E., İrem Atay Balkan, Mercanoǧlu, G., Yeşilada, E. |
| Přispěvatelé: |
Kirmizibekmez, H., Bassarello, C., Piacente, S., Celep, E., Atay, I., Mercanoglu, G., Yeşilada, E., Yeditepe Üniversitesi |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| Popis: |
From the MeOH extract of Hypericum calycinum, two caffeoylquinic acid derivatives, butyl chlorogenate (1), and chlorogenic acid (2), seven flavonoids, quercetin (3), quercitrin (4), hyperoside (5), isoquercitrin (6), miquelianin (7), rutin (8) and I3,II8-biapigenin (9) and two flavanols, (+)-catechin (10) and (-)-epicatechin (11) were isolated. Identification of the isolates was carried out by spectroscopic analysis including 1D and 2D NMR experiments as well as mass spectrometry. Free radical scavenging activities of the isolated compounds were determined in in-vitro 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide (NO) scavenging models. The compounds showed strong DPPH and moderate NO scavenging activities in a concentration dependent manner. (+)-Catechin and (-)-epicatechin were found to be the most active compounds with IC50 values of 4.16 and 4.67 µM for DPPH and 190 and 170 µM for NO scavenging activities, respectively. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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