Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys: A Randomized Clinical Trial
| Autor: | Schwimmer, Jeffrey B, Ugalde-Nicalo, Patricia, Welsh, Jean A, Angeles, Jorge E, Cordero, Maria, Harlow, Kathryn E, Alazraki, Adina, Durelle, Janis, Knight-Scott, Jack, Newton, Kimberly P, Cleeton, Rebecca, Knott, Cynthia, Konomi, Juna, Middleton, Michael S, Travers, Curtis, Sirlin, Claude B, Hernandez, Albert, Sekkarie, Ahlia, McCracken, Courtney, Vos, Miriam B |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | JAMA, vol 321, iss 3 Schwimmer, Jeffrey B; Ugalde-Nicalo, Patricia; Welsh, Jean A; Angeles, Jorge E; Cordero, Maria; Harlow, Kathryn E; et al.(2019). Effect of a Low Free Sugar Diet vs Usual Diet on Nonalcoholic Fatty Liver Disease in Adolescent Boys A Randomized Clinical Trial. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 321(3), 256-265. doi: 10.1001/jama.2018.20579. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2vc682n4 |
| DOI: | 10.1001/jama.2018.20579. |
| Popis: | Importance:Pediatric guidelines for the management of nonalcoholic fatty liver disease (NAFLD) recommend a healthy diet as treatment. Reduction of sugary foods and beverages is a plausible but unproven treatment. Objective:To determine the effects of a diet low in free sugars (those sugars added to foods and beverages and occurring naturally in fruit juices) in adolescent boys with NAFLD. Design, Setting, and Participants:An open-label, 8-week randomized clinical trial of adolescent boys aged 11 to 16 years with histologically diagnosed NAFLD and evidence of active disease (hepatic steatosis >10% and alanine aminotransferase level ≥45 U/L) randomized 1:1 to an intervention diet group or usual diet group at 2 US academic clinical research centers from August 2015 to July 2017; final date of follow-up was September 2017. Interventions:The intervention diet consisted of individualized menu planning and provision of study meals for the entire household to restrict free sugar intake to less than 3% of daily calories for 8 weeks. Twice-weekly telephone calls assessed diet adherence. Usual diet participants consumed their regular diet. Main Outcomes and Measures:The primary outcome was change in hepatic steatosis estimated by magnetic resonance imaging proton density fat fraction measurement between baseline and 8 weeks. The minimal clinically important difference was assumed to be 4%. There were 12 secondary outcomes, including change in alanine aminotransferase level and diet adherence. Results:Forty adolescent boys were randomly assigned to either the intervention diet group or the usual diet group (20 per group; mean [SD] age, 13.0 [1.9] years; most were Hispanic [95%]) and all completed the trial. The mean decrease in hepatic steatosis from baseline to week 8 was significantly greater for the intervention diet group (25% to 17%) vs the usual diet group (21% to 20%) and the adjusted week 8 mean difference was -6.23% (95% CI, -9.45% to -3.02%; P |
| Databáze: | OpenAIRE |
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