Characteristics of Mesenchymal Stem Cells Derived From the Apical Papilla of a Supernumerary Tooth Compared to Stem Cells Derived From the Dental Pulp
| Autor: | GÖNEN, ZEYNEP BURÇİN, Demirci, Selami, Dogan, Aysegul, Sardogan, Aysegul, Ekizer, Abdullah, ALKAN, ALPER, Sahin, Fikrettin |
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| Přispěvatelé: | Gönen, Zeynep Burçin, Demirci, Selami, Doğan, Ayşegül, Sardoğan, Ayşegül, Ekizer, Abdullah, Alkan, Alper, Şahin, Fikrettin, Yeditepe Üniversitesi, ALKAN, ALPER |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
stem cell
stomatognathic diseases lcsh:R5-920 stomatognathic system apical papilla GÖNEN Z. B. Demirci S. Dogan A. Sardogan A. Ekizer A. ALKAN A. Sahin F. -Characteristics of Mesenchymal Stem Cells Derived From the Apical Papilla of a Supernumerary Tooth Compared to Stem Cells Derived From the Dental Pulp- ERCIYES MEDICAL JOURNAL cilt.41 ss.18-24 2019 dental pulp lcsh:Medicine (General) Genel ve Dahili Tıp supernumerary tooth |
| Zdroj: | Erciyes Medical Journal, Vol 41, Iss 1, Pp 18-24 (2019) |
| ISSN: | 2149-2247 |
| Popis: | Objective: There are several comparative studies that were conducted to explain the specific properties of oral tissue derived mesenchymal stem cells (MSC). However, apical papilla stem cells derived from supernumerary teeth (ST-APSCs) have not been characterized for their MSC properties yet. Materials and Methods: In the present study, ST-APSCs were isolated and characterized from a nonsyndromic male patient to evaluate the MSC characteristics. Dental pulp stem cells (DPSCs) and ST-APSCs were isolated and characterized for mesenchymal surface markers. Cells were differentiated into osteo-, chondro-, and adipogenic cell types. Results: Both cell types expressed the MSC surface markers. When DPSCs and ST-APSCs were cultured in differentiation media promoting transformation to osteo-, chondro-, and adipo-genic lineages, both showed calcium mineralization, chondrogenic mass formation, and lipid accumulation. However, DPSCs derived from a wisdom tooth demonstrated more differentiation potential to osteo- and chondro-genic cell types compared to ST-APSCs. Conclusion: Overall, ST-APSCs were characterized by their MSC properties and were able to differentiate into three cell lineages. However, they were less potent for osteo- and chondro-genic cell lineage specification compared to DPSCs derived from a wisdom tooth. |
| Databáze: | OpenAIRE |
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