Undifferentiated Spondyloarthropathies in Brazilians: Importance of HLA-B27 and the B7-CREG Alleles in Characterization and Disease Progression

Autor: Sampaio-Barros, Pd, Conde, Ra, eduardo donadi, Kraemer, Mhs, Persoli, L., Coimbra, Ib, Costallat, Ltl, Samara, Am, Bertolo, Mb
Přispěvatelé: Universidade Estadual de Campinas (UNICAMP), Laboratory of Rheumatology, Universidade de São Paulo (USP), Haematology Unit, Rheumatology Unit
Jazyk: angličtina
Rok vydání: 2003
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Zdroj: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Web of Science
ResearcherID
Popis: Made available in DSpace on 2022-04-29T08:42:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2003-12-01 Objective. To analyze the profile of the HLA-B27 and B7 cross-reactive group (CREG) alleles and the role of these markers in disease characterization and progression in patients with undifferentiated spondyloarthropathies (uSpA). Methods. A total of 80 patients with a diagnosis of uSpA (40 HLA-B27 positive and 40 HLA-B27 negative) were prospectively studied for 2 years. The control group consisted of 66 HLA-B27 positive and 112 HLA-B27 negative individuals without a history of seronegative SpA. HLA-B alleles were typed at low (B7-CREG alleles, i.e., B*7, B*54, B*55, B*56, B*40, B*42) or high resolution (B*27 alleles) using polymerase chain reaction-amplified DNA hybridized with sequence-specific oligonucleotide probes. Results. HLA-B*2705 was the most frequent allele, observed in 92.5% of the patients and in 77% of the controls, followed by the HLA-B*2702, observed in 5% of the patients and in 12% of the controls. HLA-B*2704 was observed in only one patient (2.5%), and was absent in the control population. HLA-B*2703 (6%) and HLA-B*2707 (5%) alleles were observed only in controls. No associations between HLA-B*27 alleles or B7-CREG alleles and any specific manifestation of uSpA were observed. HLA-B27 positive patients more frequently presented juvenile onset SpA (p = 0.002) and progression to ankylosing spondylitis (AS) (p = 0.03) than did HLA-B27 negative patients. The B7-CREG alleles were observed in 5% of the HLA-B27 positive uSpA group, in 25% of the HLA-B27 negative uSpA group, in 7% of the HLA-B27 positive controls, and in 13% of the HLA-B27 negative controls; a significant association was observed between the presence of the B7-CREG and the HLA-B27 negative uSpA group (p = 0.012). Conclusion. The frequency of the HLA-B*2705 allele among the B27 positive uSpA patients of this series was closely similar to that reported for patients with ankylosing spondylitis (AS). The presence of HLA-B*27 alleles was associated with the progression to AS, and the presence of B7-CREG was associated with uSpA in the HLA-B27 negative group. Department of Internal Medicine State University of Campinas Faculty of Medical Sciences, Campinas Laboratory of Rheumatology Immunology Unit State University of Sao Paulo, Ribeirão Preto Department of Clinical Pathology Haematology Unit Rheumatology Unit Department of Rheumatology Rheumatology Unit Faculty of Medical Sciences State University of Campinas, Campinas Departamento de Clinica Medica Faculdade de Ciencias Medicas Univ. Estadua de Campinas (UNICAMP), Campinas SP, CEP 13081-970
Databáze: OpenAIRE
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