Role of thigh muscle cross-sectional area and strength in progression of knee cartilage degeneration over 48 months - data from the Osteoarthritis Initiative
| Autor: | Goldman, LH, Tang, K, Facchetti, L, Heilmeier, U, Joseph, GB, Nevitt, MC, McCulloch, CE, Souza, RB, Link, TM |
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| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
Aging Knee Joint Arthritis Pain Research Clinical Sciences Biomedical Engineering Muscle cross-sectional area Human Movement and Sports Sciences musculoskeletal system Magnetic Resonance Imaging Extension strength Arthritis & Rheumatology Cartilage Thigh Clinical Research Musculoskeletal Osteoarthritis Humans Knee Longitudinal Studies Muscle Strength Chronic Pain Articular MR imaging |
| Zdroj: | Osteoarthritis and cartilage, vol 24, iss 12 Goldman, LH; Tang, K; Facchetti, L; Heilmeier, U; Joseph, GB; Nevitt, MC; et al.(2016). Role of thigh muscle cross-sectional area and strength in progression of knee cartilage degeneration over 48 months-data from the Osteoarthritis Initiative. OSTEOARTHRITIS AND CARTILAGE, 24(12), 2082-2091. doi: 10.1016/j.joca.2016.07.004. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/50k2372b |
| DOI: | 10.1016/j.joca.2016.07.004. |
| Popis: | ObjectiveTo determine in a 48-month longitudinal study the association of thigh muscle cross-sectional area (CSA) and strength on progression of morphologic knee cartilage degeneration using 3T magnetic resonance imaging (MRI).DesignSeventy Osteoarthritis Initiative (OAI) subjects aged 50-60 years, with no radiographic evidence of osteoarthritis (OA) and constant muscle strength over 48 months as measured by isometric knee extension testing were included. Baseline right thigh muscle CSAs were assessed on axial T1-weighted magnetic resonance (MR) images, and extensor to flexor CSA ratios were calculated. Degenerative knee abnormalities at baseline and 48-months were graded on right knee 3T MRIs using a modified whole organ MRI score (WORMS). Statistical analysis employed Student's t-tests and multivariable regression models adjusted for age, body mass index and gender.ResultsExtension strength was significantly and positively correlated with baseline thigh muscle CSA (r=0.65, P |
| Databáze: | OpenAIRE |
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