Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs

Autor: Schuurman, W., Levett, P.A., Pot, M.W., Weeren, P.R. van, Dhert, W.J., Hutmacher, D.W., Melchels, F.P., Klein, T.J., Malda, J.
Rok vydání: 2013
Předmět:
Zdroj: Macromolecular Bioscience, 13, 551-61
Macromolecular Bioscience, 13, 5, pp. 551-61
ISSN: 1616-5187
Popis: Item does not contain fulltext Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness and swelling properties. GelMA solutions have a low viscosity at 37 degrees C, which is incompatible with most biofabrication approaches. However, incorporation of hyaluronic acid (HA) and/or co-deposition with thermoplastics allows gelMA to be used in biofabrication processes. These attributes may allow engineered constructs to match the natural functional variations in cartilage mechanical and geometrical properties.
Databáze: OpenAIRE
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