Relevance of increased serum cystatin C to vascular alterations in obese children

Autor: Dubern, B., Lafarge, J. -C., Fellahi, S., Naour, N., Copin, N., Bastard, J. -P., Simon, C., Clement, K., Bonnet, D., Tounian, P., Guerre-Millo, M.
Přispěvatelé: ProdInra, Migration, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC), Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Tenon [AP-HP], Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Université de Strasbourg (UNISTRA), Ctr Res Human Nutr Ile France, Partenaires INRAE, Université Paris Descartes - Paris 5 (UPD5), Fondation pour la Recherche Medicale, Programme Hospitalier de Recherche Clinique, Assistance Publique des Hopitaux de Paris [AOR 02076], French National Agency of Research (OBCAT) [ANR-05-PCOD-026-01], DANONE/Fondation pour la Recherche Medicale, Commission of the European Communities (Collaborative Project ADAPT) [HEALTH-F262008-201100], Institut de Cardiométabolisme et Nutrition - Institute of Cardiometabolism and Nutrition, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: International Journal of Pediatric Obesity
International Journal of Pediatric Obesity, 2012, 7 (5), pp.374-381. ⟨10.1111/j.2047-6310.2012.00053.x⟩
International Journal of Pediatric Obesity, Taylor & Francis, 2012, 7 (5), pp.374-381. ⟨10.1111/j.2047-6310.2012.00053.x⟩
ISSN: 1747-7166
1747-7174
DOI: 10.1111/j.2047-6310.2012.00053.x
Popis: International audience; Objective: Epidemiological studies report a positive relationship between serum cystatin C and cardiovascular outcomes in adults. Here, we tested the relevance of cystatin C as a biomarker for early vascular alterations in severely obese children. Methods: Two hundred nineteen obese (140 girls; age = 11.7 +/- 2.7 years, BMI Z-score = 4.7 +/- 1.2 SD) and 262 non-obese children (129 girls; age = 11.6 +/- 0.6 years, body mass index [ BMI] Z-score = 0.1 +/- 1.0 SD). Serum cystatin C was measured by immunonephelometry. Intima media thickness (IMT), incremental elastic modulus, and flow-mediated and glyceryl-trinitrate-mediated dilations were determined at the common carotid artery and the brachial artery in obese children. Results: Obese children had significantly higher serum cystatin C than normal weight controls (0.86 +/- 0.01 vs. 0.80 +/- 0.01, P < 0.0001). In obese children, serum cystatin C correlates positively with BMI and the homeostasis model assessment index and negatively with the quantitative insulin sensitivity check index and adiponectin. A positive relationship was found between serum cystatin C and carotid IMT (r = 0.23, P = 0.0005), which remained significant in multivariate models adjusted for BMI (P = 0.01) and adiponectin with a trend towards significance (P = 0.05). Conclusion: This study positions cystatin C and adiponectin as covariables associated with arterial wall thickness in obese children. Although the underlying pathophysiology linking cystatin C to early vascular disease remains to be deciphered, cystatin C may represent a novel adipose tissue-derived biomarker implicated in obesity-related comorbidities early in life.
Databáze: OpenAIRE
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