Development of Tyrosine-Based Radiotracer Tc99m-N4-Tyrosine for Breast Cancer Imaging
| Autor: | Kong, Fan-Lin, Ali, Mohammad S., Rollo, Alex, Smith, Daniel L., Zhang, Yinhan, Yu, Dong-Fang, Yang, David J. |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Journal of Biomedicine and Biotechnology, Vol 2012 (2012) |
| ISSN: | 1110-7251 1110-7243 |
| Popis: | The purpose of this study was to develop an efficient way to synthesize Tc99m-O-[3-(1,4,8,11-tetraazabicyclohexadecane)-propyl]-tyrosine (Tc99m-N4-Tyrosine), a novel amino acid-based radiotracer, and evaluate its potential in breast cancer gamma imaging. Precursor N4-Tyrosine was synthesized using a 5-step procedure, and its total synthesis yield was 38%. It was successfully labeled with Tc99m with high radiochemical purity (>95%). Cellular uptake of Tc99m-N4-Tyrosine was much higher than that of Tc99m-N4 and the clinical gold standard 18F-2-deoxy-2-fluoro-glucose (18F-FDG) in rat breast tumor cells in vitro. Tissue uptake and dosimetry estimation in normal rats revealed that Tc99m-N4-Tyrosine could be safely administered to humans. Evaluation in breast tumor-bearing rats showed that although Tc99m-N4-Tyrosine appeared to be inferior to 18F-FDG in distinguishing breast tumor tissue from chemical-induced inflammatory tissue, it had high tumor-to-muscle uptake ratios and could detect breast tumors clearly by planar scintigraphic imaging. Tc99m-N4-Tyrosine could thus be a useful radiotracer for use in breast tumor diagnostic imaging. |
| Databáze: | OpenAIRE |
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