The pedunculopontine nucleus as alternative target for deep brain stimulation
| Autor: | Marcel Antonius Johannes Lourens, Hil Meijer, Tjitske Heida, Gils, Stephanus A. |
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| Rok vydání: | 2009 |
| Předmět: | |
| Zdroj: | Proceedings of the 4th Annual symposium of the IEEE-EMBS Benelux Chapter University of Twente Research Information (Pure Portal) |
| Popis: | Parkinson’s disease (PD) is a neurodegenerative disease associated with motor and nonmotor symptoms. Deep brain stimulation (DBS) is a surgical treatment where an electrode is implanted in a certain area in the brain. In PD this is mostly done in the subthalamic nucleus (STN) or the globus pallidus interna (GPi). High frequency stimulation (~130 Hz) is often a successful treatment. The pedunculopontine nucleus (PPN) has recently been suggested as a new therapeutic target for DBS, particularly for patients with severe gait and postural impairment [2]. Stimulation at this site is typically delivered at low frequencies in contrast to the high frequency stimulation required for therapeutic benefit in STN [2]. Despite real therapeutic successes, the fundamental physiological mechanisms underlying the effect of DBS are still not understood. To get a better understanding of PPN stimulation we construct a computational model for PPN Type I neurons. |
| Databáze: | OpenAIRE |
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