Toxic Epidermal Necrolysis Successfully Treated With Infliximab
| Autor: | Ramírez Escobar, Andrés Felipe, Serrano Reyes, Carlos Daniel |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Repositorio ICESI Universidad ICESI instacron:Universidad ICESI |
| Popis: | Toxic epidermal necrolysis (TEN) is a life-threatening drug-induced cutaneous reaction characterized by widespread apoptosis and detachment of the epidermis. The main causes of death are secondary infections resulting from epidermal damage and multiorgan failure [1]. The severity of illness score (SCORTEN) [2] analyzes 7 independent risk factors and predicts mortality. Older age, significant comorbidity, and greater skin involvement correlate with a worse prognosis [2]. The pathogenesis of TEN is unknown. Several studies suggest that tumor necrosis factor (TNF) α released from inflammatory cells and activated keratinocytes in the epidermis plays an important role in the immune response by inducing direct cytotoxicity and apoptosis [3]. |
| Databáze: | OpenAIRE |
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