Endocannabinoid system protects against cryptogenic seizures

Autor:	Rijn, C.M. van, Perescis, M.F.J., Vinogradova, L.V., Luijtelaar, E.L.J.M. van
Rok vydání:	2011
Předmět:	Biological psychology Plasticity and Memory [DI-BCB_DCC_Theme 3] Biologische psychologie
Zdroj:	Pharmacological Reports, 63, 165-168 Pharmacological Reports, 63, 1, pp. 165-168
ISSN:	1734-1140
Popis:	Contains fulltext : 99304.pdf (Publisher’s version ) (Closed access) Effects of the cannabinoid antagonist rimonabant on the EEG were investigated in healthy, non-epileptic rats. The drug was administered orally at 30 mg/kg/day for 3 weeks. The EEG was recorded continuously. In 3 out of 13 rats, limbic convulsive seizures, which were not related to the time of drug administration, were observed after 5-8 days. We hypothesize that an accumulation of micro-injuries in the brain is responsible for these "spontaneous" seizures. 4 p.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::64d2a8c616422050c50854161f8b6fe0 http://hdl.handle.net/2066/99304 Zobrazit plný text záznamu Full text from SpringerLink