Synthesis of alkaloids by a diastereoselective allylation of chiral N-sulfinyl imines

Autor:	Foubelo, F., Miguel Yus
Přispěvatelé:	Universidad de Alicante. Departamento de Química Orgánica, Síntesis Asimétrica (SINTAS)
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Diastereoselective allylation Chiral N-sulfinyl imines Alkaloids Química Orgánica Desulfinylation Indium metal
Zdroj:	Scopus-Elsevier RUA. Repositorio Institucional de la Universidad de Alicante Universidad de Alicante (UA)
Popis:	The indium-promoted allylation of chiral N-sulfinyl imines represents a useful and versatile procedure to prepare chiral protected homoallyl amines in a diastereoselective manner. Desulfinylation under acidic conditions liberates easily the corresponding enantioenriched homoallyl amines. This type of compounds can be easily manipulated synthetically in order to prepare a series of natural alkaloids in an enantiopure form, using simple transformations. We thank the continued financial support from our Ministerio de Ciencia e Innovación (MCINN; projects CONSOLIDER INGENIO 2010-CDS2007-00006, CTQ2011-24151, CTQ2011-24165), the Ministerio de Economía y Competitividad (MINECO; projects CTQ2013-43446-P, CTQ2014-51912-REDC, CTQ2014-53695-P), FEDER, the Generalitat Valenciana (PROMETEO 2009/039, PROMETEOII/2014/017) and the University of Alicante.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::64955663c198b2b0c2871ba0a470fac3 https://hdl.handle.net/10045/57812 Zobrazit plný text záznamu