Attention deficit hyperactivity disorder symptoms as antecedents of later psychotic outcomes in 22q11.2 deletion syndrome
| Autor: | Niarchou, Maria, Chawner, Samuel JRA, Fiksinski, Ania, Vorstman, Jacob AS, Maeder, Johanna, Schneider, Maude, Eliez, Stephan, Armando, Marco, Pontillo, Maria, Vicari, Stefano, McDonald-McGinn, Donna M, Emanuel, Beverly S, Zackai, Elaine H, Bearden, Carrie E, Shashi, Vandana, Hooper, Stephen R, Owen, Michael J, Gur, Raquel E, Wray, Naomi R, van den Bree, Marianne BM, Thapar, Anita, International 22q11.2 Deletion Syndrome Brain and Behavior Consortium |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Adolescent Psychotic symptoms Medical and Health Sciences International 22q11.2 Deletion Syndrome Brain and Behavior Consortium Congenital Clinical Research 2.3 Psychological Behavioral and Social Science DiGeorge Syndrome 2.1 Biological and endogenous factors Humans ADHD Longitudinal Studies Aetiology Child Pediatric Psychiatry Prevention Psychology and Cognitive Sciences 22q11.2DS Attention Deficit Hyperactivity Disorder (ADHD) Brain Disorders Mental Health Inattention Psychotic Disorders Attention Deficit Disorder with Hyperactivity Disease Progression Female social and economic factors |
| Popis: | Individuals with 22q11.2 Deletion Syndrome (22q11.2DS) are at substantially heightened risk for psychosis. Thus, prevention and early intervention strategies that target the antecedents of psychosis in this high-risk group are a clinical priority. Attention Deficit Hyperactivity Disorder (ADHD) is one the most prevalent psychiatric disorders in children with 22q11.2DS, particularly the inattentive subtype. The aim of this study was to test the hypothesis that ADHD inattention symptoms predict later psychotic symptoms and/or psychotic disorder in those with 22q11.2DS. 250 children and adolescents with 22q11.2DS without psychotic symptoms at baseline took part in a longitudinal study. Assessments were performed using well-validated structured diagnostic instruments at two time points (T1 (mean age = 11.2, SD = 3.1) and T2 (mean age = 14.3, SD = 3.6)). Inattention symptoms at T1 were associated with development of psychotic symptoms at T2 (OR:1.2, p = 0.01) but weak associations were found with development of psychotic disorder (OR:1.2, p = 0.15). ADHD diagnosis at T1 was strongly associated with development of psychotic symptoms at T2 (OR:4.5, p |
| Databáze: | OpenAIRE |
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