Synthesis of 6beta-D-glucosyl and 6-nitroxy(-)-galanthamine derivatives as acetylcholinesterase inhibitors
| Autor: | PERISSUTTI, ELISA, FIORINO, FERDINANDO, SEVERINO, BEATRICE, FRECENTESE, FRANCESCO, MASSARELLI P, NENCINI C, SANTAGADA, VINCENZO, CALIENDO, GIUSEPPE |
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| Přispěvatelé: | Perissutti, Elisa, Fiorino, Ferdinando, Severino, Beatrice, Frecentese, Francesco, Massarelli, P, Nencini, C, Santagada, Vincenzo, Caliendo, Giuseppe |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Popis: | Galanthamine is an alkaloid approved for the treatment of Alzheimer’s disease. In this paper the syntheses and the anticholinesterase activities of new glucosyl and nitroxy derivatives substituted on position 6 are reported. Compounds 2, 3 and 5 presented a percentage of inhibition of 35.22%, 47.48% and 67.89 % respectively |
| Databáze: | OpenAIRE |
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