| Autor: |
Eimont, Romuald, Vailionytė, Agnė, Cėpla, Vytautas, Druceikaitė, Kristina, Inokaitis, Hermanas, Dabkevičiūtė, Laura, Sukackaitė, Eurika, Masilionis, Ignas, Ulčinas, Artūras, Samanta, Ayan, Valiokas, Ramūnas, Jekabsone, Aistė |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Vita Scientia : International conference „Vita Scientia“ : conference book : 3rd January, 2018, Vilnius / Vilnius University, Vilnius : Vita est Scientia, 2018, p. 59-59, no. 52 |
| ISSN: |
2538-791X |
| Popis: |
Self-supporting, shapeable hydrogels that consist of self-assembling synthetic peptides mimic the structural blocks of the extracellular matrix (ECM). Although they have been developed for regenerative medicine purposes [1], with a potential of grafting into patients without transplantation from organ donors, this class of materials are attractive as scaffolds for advanced cell culture/ in vitro tissue applications. In the present study, we have combined a series of peptides with functional motives (collagen, fibronectin, and laminin-like) for promoting granule layer-like organization of primary cerebellar cells and for controlling the cell attachment, neuritogenesis, cluster size and organization. We show that the micro/nanofabricated hydrogel scaffolds are applicable as multiwell plate inserts helping to analyse cell migration, differentiation, proliferation, adhesion, ultimately forming organotypic cell culture and artificial tissue structures. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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