Preserved CD4 T-cell telomere length during long-lasting HIV-2 infection --Manuscript Draft
| Autor: | Tendeiro, R., Albuquerque, A. S., Foxall, Russell B., Cavaleiro, R., Soares, R. S., Baptista, A. P., Soares, M. V., Gomes, P., Sousa, A. E. |
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| Přispěvatelé: | Repositório da Universidade de Lisboa |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins HIV-2 infection features a much slower course than HIV-1 infection, often asymptomatic for over 20 years, without antiretroviral therapy (ART). Nevertheless, CD4 T cells progressively decline, in direct correlation with immune activation and cell cycling. We report, for the first time, preserved telomere length within naive and memory CD4 subsets in prolonged HIV-2 infection despite the increased CD4 turnover. The study was supported by ANRS (French National Agency for research on AIDS and viral hepatitis) and by the European Community’s Seventh Framework Programme (FP7/2007–2013) under the project ‘Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN)’ (grant no. 223131). |
| Databáze: | OpenAIRE |
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