Reducing Boolean Networks with Backward Boolean Equivalence

Autor: Argyris, Georgios, Lluch Lafuente, Alberto, Tribastone, Mirco, Tschaikowski, Max, Vandin, Andrea
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Argyris, G, Lluch Lafuente, A, Tribastone, M, Tschaikowski, M & Vandin, A 2021, Reducing Boolean Networks with Backward Boolean Equivalence . in Computational Methods in Systems Biology : 19th International Conference, CMSB 2021, Bordeaux, France, September 22–24, 2021, Proceedings . Springer, Lecture Notes in Computer Science, vol. LNCS 12881, pp. 1-18, International Conference on Computational Methods in Systems Biology-CMSB 2021, Bordeaux, France, 22/09/2021 . https://doi.org/10.1007/978-3-030-85633-5_1
Argyris, G, Lafuente, A L, Tribastone, M, Tschaikowski, M & Vandin, A 2021, Reducing Boolean Networks with Backward Boolean Equivalence . in Computational Methods in Systems Biology . Springer, Lecture Notes in Computer Science, vol. 12881, 19 th International Conference on Computational Methods in Systems Biology, Bordeaux, France, 22/09/2021 . https://doi.org/10.1007/978-3-030-85633-5_1
DOI: 10.1007/978-3-030-85633-5_1
Popis: Boolean Networks (BNs) are established models to qualitatively describe biological systems. The analysis of BNs might be infeasible for medium to large BNs due to the state-space explosion problem. We propose a novel reduction technique called \emph{Backward Boolean Equivalence} (BBE), which preserves some properties of interest of BNs. In particular, reduced BNs provide a compact representation by grouping variables that, if initialized equally, are always updated equally. The resulting reduced state space is a subset of the original one, restricted to identical initialization of grouped variables. The corresponding trajectories of the original BN can be exactly restored. We show the effectiveness of BBE by performing a large-scale validation on the whole GINsim BN repository. In selected cases, we show how our method enables analyses that would be otherwise intractable. Our method complements, and can be combined with, other reduction methods found in the literature.
Databáze: OpenAIRE