Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty acid ester derivatives against MCF7 and hepatocellular carcinoma cell lines

Autor:	Mustufa, M. A., Aslam, A., Ozen, C., Hashmi, I. A., Naqvi, N. U. H., Mehmet Ozturk, Ali, F. I.
Přispěvatelé:	Mustufa, Muhammad Ayaz, Özen, Çiğdem, Öztürk, Mehmet
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	Steglich esterification SRB assay Abietic acid Cancer cell lines skin and connective tissue diseases Diterpene neoplasms digestive system diseases
Zdroj:	Pakistan Journal of Pharmaceutical Sciences Scopus-Elsevier
Popis:	Synthesis of twelve hitherto unreported esters of abietyl alcohol and screening of these esters against four cancer cell lines including one breast cancer line MCF7 and four hepatocellular carcinoma cell lines (HCC) Huh7, Hep3B, Snu449 and Plc has been determined using SRB assay. The Cell cycle progression showed changes in cellular behaviour after 48 and 72 hours in MCF7 and Huh7 cell lines. Abietyl alcohol was obtained from the reduction of abietic acid, a tricyclic diterpene, isolated from oleoresin of Pinus longifolia Roxberghii.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::62026926c9b6fdb188d96e88690e837e https://avesis.deu.edu.tr/publication/details/6da9aa35-5d3e-4a81-9a2a-1e1e1b801231/oai Zobrazit plný text záznamu