Hypertensie door dropgebruik
| Autor: | Seelen, M. A.J., Meijer, P. H.E.M., Braun, J., Swinkels, L. M.J.W., Waanders, H., Meinders, A. E. |
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| Přispěvatelé: | Cardio-thoracic surgery |
| Jazyk: | Dutch; Flemish |
| Rok vydání: | 1996 |
| Zdroj: | Nederlands Tijdschrift voor Geneeskunde, 140(52), 2632-2635. Bohn Stafleu van Loghum Seelen, M A J, Meijer, P H E M, Braun, J, Swinkels, L M J W, Waanders, H & Meinders, A E 1996, ' Hypertensie door dropgebruik ', Nederlands Tijdschrift voor Geneeskunde, vol. 140, no. 52, pp. 2632-2635 . |
| ISSN: | 0028-2162 |
| Popis: | In a 38-year old woman who was hospitalized because of hypertension and hypokalaemic alkalosis, the intake of liquorice (200 g per day) was proven to be the cause. A liquorice provocation test produced all the expected clinical and biochemical abnormalities. Some kinds of liquorice contain glycyrrhetic acid which inhibits the enzyme 11-β-hydroxysteroid dehydrogenase (e.g. in the kidney) leading to decreased transformation of cortisol into cortisone. The mineralocorticoid action of cortisol causes a drop in serum potassium and an increase in serum sodium concentration, together with a metabolic alkalosis, which in the patient described led to retention of water resulting in weight increase and hypertension. |
| Databáze: | OpenAIRE |
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