High Resolution Esophageal Manometry in Patients with Chagas Disease : A Cross-Sectional Evaluation

Autor: Sánchez-Montalvá, Adrián, Moris, Maria, Mego Silva, Marianela, Salvador, Fernando, Accarino, Ana María, Ramírez, Kathleen, Azpiroz Vidaur, Fernando, Ruiz-de-Leon, Antonio, Molina, Israel, Universitat Autònoma de Barcelona. Departament de Medicina, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd)
Rok vydání: 2016
Zdroj: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Popis: Gastrointestinal involvement affects 30-40% of the patients with chronic Chagas disease. Esophageal symptoms appear once the structural damage is established. Little is known about the usefulness of high resolution manometry to early identification of esophageal involvement. We performed a cross-sectional study at the Vall d'Hebron University Hospital (Barcelona, Spain) between May 2011 and April 2012. Consecutive patients diagnosed with Chagas disease in the chronic phase were offered to participate. All patients underwent a structured questionnaire about digestive symptoms, a barium esophagogram (Rezende classification) and an esophageal high resolution manometry (HRM). A control group of patients with heartburn who underwent an esophageal HRM in our hospital was selected. 62 out of 73 patients that were included in the study fulfilled the study protocol. The median age of the Chagas disease group (CG) was 37 (IQR 32-45) years, and 42 (67.7%) patients were female. Twenty-seven (43.5%) patients had esophageal symptoms, heartburn being the most frequent. Esophagogram was abnormal in 5 (8.77%). The esophageal HRM in the CG showed a pathological motility pattern in 14 patients (22.6%). All of them had minor disorders of the peristalsis (13 with ineffective esophageal motility and 1 with fragmented peristalsis). Hypotonic lower esophageal sphincter was found more frequently in the CG than in the control group (21% vs 3.3%; p
Databáze: OpenAIRE
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