| Autor: |
Erkisi, M., Doran, F., Burgut, R., Salih O. Colakoglu, Karaer, P., Varinli, S. |
| Přispěvatelé: |
Çukurova Üniversitesi |
| Jazyk: |
angličtina |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| Popis: |
Fifty-four early stage gastric cancer patients were investigated for the presence of AFP and CEA. In their tumor specimens 9 patients showed AFP, 14 patients showed CEA and 9 patients showed AFP and CEA positivity by immunoperoxidase staining. Mean age was younger in AFP (+) patients (44.35 ± 8.4) than others (53.5 ± 8.0, p=0.0006). There was a significant correlation between the AFP and CEA positivity and stage of the disease (p=0.001, p=0.001). Lymphatic and/or venous invasion were more prominent in tumors with positive AFP staining (p=0.04) but serosal invasion was more frequent in CEA (+) tumors (p=0.05). The incidence of poorly differentiated tumors was high in AFP (+) tumors (p=0.034). Disease free survival (DFS) and overall survival (OS) were significantly shorter in patients with high serum AFP and CEA levels (p=0.0001). As conclusion AFP and CEA content of the tumor is a very important parameter in the management and prognosis of gastric cancer patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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