Phenotype of Inflammatory Bowel Disease at Diagnosis in the Netherlands

Autor: Nuij, Veerle, Zelinkova, Zuzana, Rijk, Marno, Beukers, Ruud, Ouwendijk, Rob, Quispel, Rutger, van Tilburg, Antonie, Tang, Thjon, Smalbraak, Hermen, Bruin, Karlien, Lindenburg, Flordeliz, Peyrin-Biroulet, Laurent, Van Der Woude, C. Janneke
Přispěvatelé: Erasmus University Medical Center [Rotterdam] (Erasmus MC), Department of Gastroenterology and Hepatology [Amphia Hospital], Amphia Hospital Breda, Department of Gastroenterology and Hepatology [Albert Schweitzer Hospital], Albert Schweitzer Hospital, Department of Gastroenterology and Hepatology [Ikazia Hospital], IkaziaHospital Rotterdam, Department of Gastroenterology and Hepatology [Reinier de Graaf Gasthuis], Reinier de Graaf Gasthuis, Department of Gastroenterology and Hepatology [Sint Franciscus Gasthuis], Sint Franciscus Gasthuis, Department of Gastroenterology and Hepatology [IJsselland Hospital], IJsselland Hospital, Department of Internal Medicine [Lievensberg Hospital], Lievensberg Hospital, Department of Gastroenterology and Hepatology [Tweesteden Hospital], Tweesteden Hospital, Department of Gastroenterology and Hepatology [Franciscus Hospital], Franciscus Hospital, Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases, Lippincott, Williams & Wilkins, 2013, 19 (10), pp.2215-2222. ⟨10.1097/MIB.0b013e3182961626⟩
ISSN: 1078-0998
1536-4844
DOI: 10.1097/MIB.0b013e3182961626⟩
Popis: International audience; BackgroundTo describe the clinical characteristics of inflammatory bowel disease (IBD) at diagnosis in The Netherlands at the population level in the era of biologics.MethodsAll patients with newly diagnosed IBD (diagnosis made between January 1, 2006 and January 1, 2007) followed in 9 general hospitals in the southwest of the Netherlands were included in this population-based inception cohort study.ResultsA total of 413 patients were enrolled, of which 201 Crohn’s disease (CD) (48.7%), 188 ulcerative colitis (UC) (45.5%), and 24 IBD unclassified (5.8%), with a median age of 38 years (range, 14–95). Seventy-eight patients with CD (38.8%) had ileocolonic disease and 73 patients (36.3%) had pure colonic disease. In 8 patients (4.0%), the upper gastrointestinal tract was involved. Nineteen patients with CD (9.5%) had perianal disease. Thirty-nine patients with CD (19.4%) had stricturing phenotype. Of the patients with UC and IBDU, 39 (18.4%) suffered from pancolitis and 61 (29%) from proctitis. Severe endoscopic lesions at diagnosis were seen in 119 patients (28.8%, 68 CD, 49 UC, and 2 IBDU), whereas 98 patients (23.7%) had severe histological disease activity. Thirteen patients (3.1%, 10 CD and 3 UC) had extraintestinal manifestations at diagnosis. Twenty-three patients (5.6%, 20 CD and 3 UC) had fistula at diagnosis.ConclusionsIn this cohort, 31% of the patients with CD had complicated disease at diagnosis, 39% had ileocolonic disease, 9.5% had perianal disease, and in 4% the upper gastrointestinal tract was involved. Most patients with UC suffered from left-sided colitis (51%). Severe endoscopic lesions were reported in 34% of the patients with CD and 26% of the patients with UC. Three percent of the patients with IBD had extraintestinal manifestations.
Databáze: OpenAIRE
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