| Autor: |
Hoh Kam, Jaimie, Lynch, Aisling, Begum, Rana, Cunea, Alex, Jeffery, Glen |
| Jazyk: |
angličtina |
| Předmět: |
|
| Zdroj: |
Experimental Eye Research. :59-66 |
| ISSN: |
0014-4835 |
| DOI: |
10.1016/j.exer.2015.03.023 |
| Popis: |
Retinal ageing results in chronic inflammation, extracellular deposition, including that of amyloid beta (Aβ) and declining visual function. In humans this can progress into age-related macular degeneration (AMD), which is without cure. Therapeutic approaches have focused on systemic immunotherapies without clinical resolution. Here, we show using aged mice that 2-Hydroxypropyl-β-cyclodextrin, a sugar molecule given as eye drops over 3 months results in significant reductions in Aβ by 65% and inflammation by 75% in the aged mouse retina. It also elevates retinal pigment epithelium specific protein 65 (RPE65), a key molecule in the visual cycle, in aged retina. These changes are accompanied by a significant improvement in retinal function measured physiologically. 2-Hydroxypropyl-β-cyclodextrin is as effective in reducing Aβ and inflammation in the complement factor H knockout (Cfh−/−) mouse that shows advanced ageing and has been proposed as an AMD model. β-cyclodextrin is economic, safe and may provide an efficient route to reducing the impact of retinal ageing. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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