Insulin signal decrease in muscle but not in the liver of castrated male rats from chronic exposure to fluoride

Autor: Chiba, Fernando Yamamoto [UNESP], Colombo, Natália Helena [UNESP], Shirakashi, Daisy Jaqueline [UNESP], Gomes, Wendrew Douglas De Souza [UNESP], Moimaz, Suzely Adas Saliba [UNESP], Garbin, Cléa Adas Saliba [UNESP], Silva, Cristina Antoniali [UNESP], Sumida, Doris Hissako [UNESP]
Přispěvatelé: Universidade Estadual Paulista (Unesp), Universidade Estadual Paulista (UNESP)
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Web of Science
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Scopus
Popis: Made available in DSpace on 2013-08-12T19:24:22Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01 Made available in DSpace on 2013-09-30T18:29:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:43:03Z No. of bitstreams: 0 Made available in DSpace on 2014-05-20T13:43:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Fundação para o Desenvolvimento da UNESP (FUNDUNESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) With half the animals as controls without fluoride (F) in their drinking water, 16 of 32 seven-week-old castrated male Wistar rats were administered NaF in their drinking water and F contained in food pellets (estimated total F intake: 4.0 mg F/kg bw/day). After 42 days, determinations were made of the insulin receptor substrate (pp185-IRS-1/IRS/2), tyrosine phosphorylation status, and the extent of glycemia and insulinemia. This chronic treatment with F promoted: 1) decrease in the pp185 tyrosine phosphorylation status in the muscle tissue but not in the liver; 2) increase in the plasma F level; 3) no alteration in glycemia and insulinemia; 4) an increase in insulin resistance. Univ Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, UNESP, BR-16015050 Aracatuba, SP, Brazil Univ Estadual Paulista, Dept Child & Social Dent, Dent Sch Aracatuba, UNESP, BR-16015050 Aracatuba, SP, Brazil Univ Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, UNESP, BR-16015050 Aracatuba, SP, Brazil Univ Estadual Paulista, Dept Child & Social Dent, Dent Sch Aracatuba, UNESP, BR-16015050 Aracatuba, SP, Brazil FAPESP: 08/52688-8
Databáze: OpenAIRE
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