Lack of relation between human T-lymphotropic virus type I infection and systemic lupus erythematosus in Jamaica, West Indies
| Autor: | Murphy, EL, De Ceulaer, K, Williams, W, Clark, JW, Saxinger, C, Gibbs, WN, Blattner, WA |
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| Rok vydání: | 1988 |
| Předmět: |
Aged
80 and over Adult Male Jamaica Lupus Erythematosus Adolescent viruses Systemic virus diseases and over Middle Aged HTLV-I Infections HTLV-I Antibodies immune system diseases hemic and lymphatic diseases Africa 80 and over Lupus Erythematosus Systemic Humans Female skin and connective tissue diseases Child Aged |
| Zdroj: | Journal of acquired immune deficiency syndromes, vol 1, iss 1 Murphy, EL; De Ceulaer, K; Williams, W; Clark, JW; Saxinger, C; Gibbs, WN; et al.(1988). Lack of relation between human T-lymphotropic virus type I infection and systemic lupus erythematosus in Jamaica, West Indies.. Journal of acquired immune deficiency syndromes, 1(1), 18-22. UCSF: Retrieved from: http://www.escholarship.org/uc/item/8w55w7qm |
| Popis: | To determine whether systemic lupus erythematosus (SLE) is associated with human T-lymphotropic virus, type I (HTLV-I) infection in Jamaica, an endemic area for the virus, we studied 63 patients with SLE at the University Hospital of the West Indies in Kingston. Antibodies to HTLV-I were measured by an enzyme-linked immunosorbent assay (ELISA) technique using purified disrupted whole virus as antigen, with confirmation by p24 protein RIA or competitive binding. Four of 63 SLE patients were HTLV-I seropositive (6.3%). There was no evidence for excess HTLV-I infection in SLE patients when their age- and sex-standardized HTLV-I seroprevalence rate was compared to that of a large group of healthy food service employees. None of 13 patients with rheumatoid arthritis were seropositive for HTLV-I. We conclude that HTLV-I infection does not appear to be linked with SLE in Jamaica. |
| Databáze: | OpenAIRE |
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