Risk factors for in-hospital mortality in patients with acute myocardial infarction during the COVID-19 outbreak

Autor: Solano-Lopez J, Luis Zamorano J, Sanz A, Amat-Santos I, Sarnago F, Ibanes E, Sanchis J, Blas J, Gomez-Hospital J, Martinez S, Maneiro-Melon N, Gaitan R, D'Gregorio J, Salido L, Mestre J, Sanmartin M, Sanchez-Recalde A
Rok vydání: 2020
Zdroj: REVISTA ESPANOLA DE CARDIOLOGIA
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Revista Espanola De Cardiologia (english Ed.)
ISSN: 0300-8932
1885-5857
Popis: INTRODUCTION AND OBJECTIVES: Despite advances in treatment, patients with acute myocardial infarction (AMI) still exhibit unfavorable short- and long-term prognoses. In addition, there is scant evidence about the clinical outcomes of patients with AMI and coronavirus disease 2019 (COVID-19). The objective of this study was to describe the clinical presentation, complications, and risk factors for mortality in patients admitted for AMI during the COVID-19 pandemic.; METHODS: This prospective, multicenter, cohort study included all consecutive patients with AMI who underwent coronary angiography in a 30-day period corresponding chronologically with the COVID-19 outbreak (March 15 to April 15, 2020). Clinical presentations and outcomes were compared between COVID-19 and non-COVID-19 patients. The effect of COVID-19 on mortality was assessed by propensity score matching and with a multivariate logistic regression model.; RESULTS: In total, 187 patients were admitted for AMI, 111 with ST-segment elevation AMI and 76 with non-ST-segment elevation AMI. Of these, 32 (17%) were diagnosed with COVID-19. GRACE score, Killip-Kimball classification, and several inflammatory markers were significantly higher in COVID-19-positive patients. Total and cardiovascular mortality were also significantly higher in COVID-19-positive patients (25% vs 3.8% [P 140 (OR, 23.45; 95%CI, 2.52-62.51; P=.005) and COVID-19 (OR, 6.61; 95%CI, 1.82-24.43; P=.02) were independent predictors of in-hospital death.; CONCLUSIONS: During this pandemic, a high GRACE score and COVID-19 were independent risk factors associated with higher in-hospital mortality. Copyright © 2020 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.
Databáze: OpenAIRE
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