Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid
| Autor: | Yang, X, Toste, FD |
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| Rok vydání: | 2016 |
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| Zdroj: | Chemical science, vol 7, iss 4 Yang, X; & Toste, FD. (2016). Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid. Chemical Science, 7(4), 2653-2656. doi: 10.1039/c5sc04202j. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/3gg2m2vd |
| Popis: | © The Royal Society of Chemistry 2016. We describe the asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid, generating an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity. The products are easily transformed into their corresponding 1,5- and 1,4-ketoaldehyde derivatives, which are both important building blocks in organic synthesis. |
| Databáze: | OpenAIRE |
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