Digitally stained confocal microscopy through deep learning

Autor: Combalia Escudero, Marc, Pérez Ankar, Javiera, García Herrera, Adriana, Alos, Llúcia, Vilaplana Besler, Verónica, Marqués Acosta, Fernando, Puig, Susana, Malvehy, Josep
Přispěvatelé: Universitat Politècnica de Catalunya. Departament de Teoria del Senyal i Comunicacions, Universitat Politècnica de Catalunya. GPI - Grup de Processament d'Imatge i Vídeo
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
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Popis: Specialists have used confocal microscopy in the ex-vivo modality to identify Basal Cell Carcinoma tumors with an overall sensitivity of 96.6% and specificity of 89.2% (Chung et al., 2004). However, this technology hasn’t established yet in the standard clinical practice because most pathologists lack the knowledge to interpret its output. In this paper we propose a combination of deep learning and computer vision techniques to digitally stain confocal microscopy images into H&E-like slides, enabling pathologists to interpret these images without specific training. We use a fully convolutional neural network with a multiplicative residual connection to denoise the confocal microscopy images, and then stain them using a Cycle Consistency Generative Adversarial Network
Databáze: OpenAIRE