Demographics of antibiotic persistence
| Autor: | Silvia Kollerova, Lionel Jouvet, Ulrich Steiner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Zdroj: | Kollerova, S, Jouvet, L & Steiner, U 2016, ' Demographics of antibiotic persistence ', Evolutionary Demography Society Meeting 2016, Charlottesville VA, United States, 02/10/2016-05/10/2016 . < http://evodemo2016.weebly.com/titles-with-abstracts.html > University of Southern Denmark |
| Popis: | Persister cells, cells that can survive antibiotic exposure but lack heritable antibiotic resistance, are assumed to play a crucial role for the evolution of antibiotic resistance. Persistence is a stage associated with reduced metabolic activity. Most previous studies have been done on batch cultures, rather than the individual level. Here, we used individual level bacteria data to confirm previous studies in how fast cells switch into a persistence stage, but our results challenge the fundamental idea that persistence comes with major costs of reduced growth (cell elongation) and division due to reduced metabolic activity. Persister cells and non-persister cells do not differ substantially in their division rate and there is mixed evidence about reduction in growth under certain conditions. In any case costs for persistence are much lower than previously assumed and suggest that persistence might even play a more prominent role for the evolution of resistance and failures of medical treatment by antibiotics as currently assumed. |
| Databáze: | OpenAIRE |
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