VRK1-mediated regulation of Tip60/KAT5 acetyltransferase during DDR
| Autor: | García González, Raúl |
|---|---|
| Rok vydání: | 2021 |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | Trabajo presentado en el ciclo de conferencias CIC, celebrado en modalidad virtual el 03 de junio de 2021. The epigenome plays a crucial role on cell differentiation and response to different environmental and cellular conditions, including DNA damage. For that purpose, it can mediate important processes such as transcription or DNA damage response (DDR). Therefore, the modulation of different epigenetic marks must be a tightly controlled process, and its deregulation is involved in the onset of different diseases, including cancer. In this context, one of the most important mechanisms of epigenome regulation consists on regulating the activity of the epigenetic enzymes through post-translational modifications. For instance, the lysine acetyltransferase 5 (KAT5, also known as Tip60) is phosphorylated by different kinases in order to modulate the epigenetic pattern throughout the cell cycle. In addition, Tip60 also plays crucial roles during DDR, including the acetylation of the lysine 16 of histone 4 (H4K16), essential for chromatin decompaction, or acetylation of ATM. To our knowledge, nonetheless, any mechanism of Tip60 modulation and activation in the context of DNA damage has been described. |
| Databáze: | OpenAIRE |
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