| Popis: |
Following the current short-term achievements in organ transplantation, health care professionals are increasingly recognizing long-term outcomes as important measures of the success of solid organ transplantation. Transplant recipients incur significant morbidity related to acute and chronic nephrotoxic side effects as well as cardiovascular disease, diabetes mellitus, malignancy, and metabolic bone disease. Medical evidence follow-up accompanied by appropriate nutritive support are necessary to improve long term surviving and well-being of transplant patients. After approval by the ethics committee, 20 patients with liver and 2 with both, liver and kidney transplantation, were included in the study. Blood samples were collected from day 0, before liver transplantation, on day 7 and one month after transplantation. In serum, concentrations of glucose, triacylglycerols, C-reactive protein (CRP) as well as total, LDL- and HDL-cholesterol were measured. Before transplantation, all biochemical parameters were out of reference values indicating intensive metabolic distress. With transplantation blood glucose levels were normalized, while after kidney transplantation additional control was necessary. Before transplantation lipid concentrations were low indicating certain malnutrition, but they were normalized after one week. However, after one month they continued to increase leading to hyperlipidaemia. Postoperative medical evidence follow-up accompanied by appropriate nutritive support are necessary to prevent development of hyperlipidaemia and to improve long term surviving and well-being of transplant patients. |
