Modelling of TH-dependent regulation of tadpole tail resorption
| Autor: | Troncale, Sylvie, Thuret, Raphaël, Fierro, Anna-Carolina, Ben, C., Pollet, Nicolas, Comet, Jean-Paul, Bernot, Gilles |
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| Přispěvatelé: | Informatique, Biologie Intégrative et Systèmes Complexes (IBISC), Université d'Évry-Val-d'Essonne (UEVE)-Centre National de la Recherche Scientifique (CNRS), Développement et évolution (DE), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Programme d'Épigénomique, Davesne, Frédéric |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
modelling
Hybrid Functional Petri Nets [INFO.INFO-PL]Computer Science [cs]/Programming Languages [cs.PL] [INFO.INFO-WB] Computer Science [cs]/Web metamorphosis [INFO.INFO-MA]Computer Science [cs]/Multiagent Systems [cs.MA] [INFO.INFO-SE] Computer Science [cs]/Software Engineering [cs.SE] [INFO.INFO-WB]Computer Science [cs]/Web [INFO.INFO-MA] Computer Science [cs]/Multiagent Systems [cs.MA] [INFO.INFO-SE]Computer Science [cs]/Software Engineering [cs.SE] tail resorption thyroid hormone [INFO.INFO-PL] Computer Science [cs]/Programming Languages [cs.PL] |
| Zdroj: | Journal of Biological Physics and Chemistry Journal of Biological Physics and Chemistry, Basel, Switzerland : Collegium Basilea (Institute of Advanced Study) ; Tbilisi : Association of Modern Scientific Investigation (AMSI), 2007, 7 (2), pp.45--50 Journal of Biological Physics and Chemistry, 2007, 7 (2), pp.45--50 |
| ISSN: | 1512-0856 |
| Popis: | International audience; Tail resorption observed at the time of amphibian metamorphosis is controlled by the thyroid hormone (TH). The inherent regulation network is complex and involves an important number of different factors. Consequently, global understanding of this biological process needs elaborate experiments. However, these experiments may be difficult to realize because of the need to manipulate in space and in time gene expression and hormonal treatments. Hence, we first modelled and simulated the biological process using Hybrid Functional Petri Nets. This powerful formalism offers a number of useful features and flexibility. Curves obtained in silico by simulations are in agreement with those observed in vivo and in vitro. Our modelling approach led us to ask pertinent biological questions, from which new hypotheses for experimental testing have emerged. |
| Databáze: | OpenAIRE |
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