Reactions of some pyrazole-3-carboxylic acids with various N,N '-binucleophiles and investigation of their antiproliferative activities
| Autor: | Kasimoʇullari, R., Maden, M., Yaglioglu, A. S., Samet Mert, Demirtaş, I. |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Scopus-Elsevier |
| Popis: | WOS: 000361782400003 Synthesis, characterization, and antiproliferative activity evaluation of a series of novel pyrazole bis-carboxamide derivatives (8-12) have been described. Synthesized molecules have been screened to evaluate their antiproliferative activities against He La (human uterus carcinoma), Vero (green monkey kidney), and C6 (Rat Brain tumor) cells as in vitro. The tests are carried out as dose-dependent assay starting from 100 mu g/mL to 500 mu g/mL. Generally the compounds have been shown to possess weak antiproliferative activity against all cell lines as compared with Cisplatin and 5-Fluorouracil. Only compound 8 shows moderate antiproliferative activity against Hela cancer cells. Scientific and Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [106T180]; Dumlupinar University Research FundDumlupinar University [52] This study was supported by the Scientific and Research Council of Turkey (Grant No: 106T180) and Dumlupinar University Research Fund (Grant No: 52). The authors would like to thank Department of Chemistry, Faculty of Sciences, and Ataturk University for providing spectroanalytical facilities and Department of Physics, Faculty of Arts and Sciences, Dumlupinar University for FT IR measurements. |
| Databáze: | OpenAIRE |
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