Temperature effects on the chromatographic behaviour of racemic 2-aminotetralins on a Whelk-O 1 stationary phase in super- and subcritical fluid chromatography
| Autor: | Selditz, U, Copinga, S, Grol, CJ, Franke, JP, de Zeeuw, RA, Wikstrom, H, Gyllenhaal, O |
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| Přispěvatelé: | Faculty of Science and Engineering, Groningen Research Institute of Pharmacy, Groningen University Institute for Drug Exploration (GUIDE) |
| Jazyk: | Dutch; Flemish |
| Rok vydání: | 1999 |
| Předmět: | |
| Zdroj: | Die Pharmazie, 3, 183-191 Pharmazie, 54(3), 183-191 |
| ISSN: | 0031-7144 |
| Popis: | The chromatographic behaviour of thirty structurally related racemic 2-amidotetralins on a cis-(3R, 4S)-Whelk-O 1 stationary phase was investigated at five different temperatures between 50 and -15 degrees C using super- or subscritical fluid chromatography (SFC/SubFC). Generally, low selectivity factors were observed for this class of analytes on this stationary phase. In particular, phenyl and benzyl substituted analogues were strongly retained, probably due to strong pi-pi interactions with the chiral selector molecule, but the enantioselectivity was low. This also counts for the two p-iodo substituted methoxy analogues, although here steric effects may be responsible for the high capacity factors. In about 10% of the cases, a decrease in the (surrounding) temperature of the column did not result in an improved selectivity. Only four compounds out of thirty could not be resolved under the given conditions. |
| Databáze: | OpenAIRE |
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