Proteolytic shedding of the macrophage scavenger receptor CD163 in multiple sclerosis
| Autor: | Fabriek, B.O., Møller, H.J., Vloet, R.P.M., Winsen, L.M. van, Hanemaaijer, R., Teunissen, C.E., Uitdehaag, B.M.J., Berg, T.K. van den, Dijkstra, C.D. |
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| Přispěvatelé: | TNO Kwaliteit van Leven |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Male
Biomedical Research Adolescent Hydrocortisone sCD163 Antigens Differentiation Myelomonocytic Enzyme-Linked Immunosorbent Assay Receptors Cell Surface Transfection multiple sclerosis Statistics Nonparametric Monocytes gelatinase B scavenger receptor Cricetulus Antigens CD Cricetinae cytokine Animals Humans CD163 antigen controlled study human Enzyme Inhibitors Metalloproteinase comparative study Cell Line Transformed Aged 80 and over analytic method adult article Middle Aged major clinical study enzyme activity aged female priority journal Matrix Metalloproteinase 9 Health protein degradation cytokine production Cytokines Matrix Metalloproteinase 2 CD163 down regulation upregulation |
| Zdroj: | Journal of Neuroimmunology, 1-2, 187, 179-186 |
| Popis: | The scavenger receptor CD163 is selectively expressed on tissue macrophages and human monocytes. CD163 has been implicated to play a role in the clearance of hemoglobin and in the regulation of cytokine production by macrophages. Membrane CD163 can be cleaved by matrix metalloproteinases (MMP) resulting in soluble CD163 (sCD163). In the present report the shedding of CD163 was investigated in multiple sclerosis (MS). An upregulation of plasma sCD163 and a down regulation of membrane CD163 in MS patients compared to healthy controls was observed. The levels of plasma sCD163 correlated with plasma MMP-9 levels in controls, but not in MS patients. Moreover, evidence was obtained for CD163-cleaving MMP activity in plasma of MS patients. Finally, the increased proteolytic shedding of CD163 correlated to reduced plasma levels of circulating inflammatory cytokines. Collectively, our results provide evidence for proteolytic shedding of CD163 in MS and suggest a possible link to cytokine production. © 2007 Elsevier B.V. All rights reserved. |
| Databáze: | OpenAIRE |
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