Recurrences of multidrug-resistant tuberculosis: Strains involved, within-host diversity, and fine-tuned allocation of reinfections
| Autor: | Pérez-Lago L, Monteserin J, Paul R, Maus SR, Yokobori N, Herranz M, Sicilia J, Acosta F, Fajardo S, Chiner-Oms Á, Matteo M, Simboli N, Comas I, Muñoz P, López B, Ritacco V, García de Viedma D |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | TRANSBOUNDARY AND EMERGING DISEASES r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica instname |
| ISSN: | 1865-1674 |
| Popis: | Recurrent tuberculosis occurs due to exogenous reinfection or reactivation/persistence. We analysed 90 sequential MDR Mtb isolates obtained in Argentina from 27 patients with previously diagnosed MDR-TB that recurred in 2018 (1-10 years, 2-10 isolates per patient). Three long-term predominant strains were responsible for 63% of all MDR-TB recurrences. Most of the remaining patients were infected by strains different from each other. Reactivation/persistence of the same strain caused all but one recurrence, which was due to a reinfection with a predominant strain. One of the prevalent strains showed marked stability in the recurrences, while in another strain higher SNP-based diversity was observed. Comparisons of intra- versus inter-patient SNP distances identified two possible reinfections with closely related variants circulating in the community. Our results show a complex scenario of MDR-TB infections in settings with predominant MDR Mtb strains. |
| Databáze: | OpenAIRE |
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